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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MFN2
All Species:
22.42
Human Site:
Y448
Identified Species:
44.85
UniProt:
O95140
Number Species:
11
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O95140
NP_001121132.1
757
86402
Y448
L
S
V
L
V
D
D
Y
Q
M
D
F
H
P
S
Chimpanzee
Pan troglodytes
XP_514395
805
91725
Y496
L
S
V
L
V
D
D
Y
Q
M
D
F
H
P
S
Rhesus Macaque
Macaca mulatta
XP_001108853
741
84052
F427
L
S
V
L
V
D
E
F
C
S
E
F
H
P
N
Dog
Lupus familis
XP_865287
757
86272
Y448
L
S
V
L
V
D
D
Y
Q
M
D
F
H
P
S
Cat
Felis silvestris
Mouse
Mus musculus
Q80U63
757
86169
Y448
L
S
V
L
V
D
E
Y
Q
M
D
F
H
P
S
Rat
Rattus norvegicus
Q8R500
757
86104
Y448
L
S
V
L
V
D
E
Y
Q
M
D
F
H
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505565
839
94273
F449
L
S
L
L
V
D
E
F
C
S
D
F
H
P
S
Chicken
Gallus gallus
XP_417640
1166
133201
Y553
L
S
V
L
V
D
E
Y
Q
A
D
F
H
P
S
Frog
Xenopus laevis
NP_001084869
756
86248
F448
L
S
V
L
V
D
E
F
Q
L
D
F
H
P
S
Zebra Danio
Brachydanio rerio
NP_001121726
757
85922
F448
L
A
V
L
V
D
D
F
H
M
D
F
H
P
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q7YU24
810
91354
F488
L
G
V
L
I
D
E
F
N
M
P
F
H
P
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23424
774
87443
F458
L
D
A
I
I
D
R
F
E
Q
P
F
D
G
S
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
93.7
62.8
97.3
N.A.
94.9
95.3
N.A.
56.8
59.9
85.1
82.9
N.A.
43.5
N.A.
34.8
N.A.
Protein Similarity:
100
94
79.7
98.9
N.A.
98.8
98.5
N.A.
71.7
62.9
93
91.9
N.A.
64.8
N.A.
55.6
N.A.
P-Site Identity:
100
100
60
100
N.A.
93.3
93.3
N.A.
66.6
86.6
80
80
N.A.
53.3
N.A.
26.6
N.A.
P-Site Similarity:
100
100
86.6
100
N.A.
100
100
N.A.
86.6
93.3
100
93.3
N.A.
73.3
N.A.
53.3
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
0
0
0
0
0
0
9
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
17
0
0
0
0
0
0
% C
% Asp:
0
9
0
0
0
100
34
0
0
0
75
0
9
0
0
% D
% Glu:
0
0
0
0
0
0
59
0
9
0
9
0
0
0
9
% E
% Phe:
0
0
0
0
0
0
0
50
0
0
0
100
0
0
0
% F
% Gly:
0
9
0
0
0
0
0
0
0
0
0
0
0
9
0
% G
% His:
0
0
0
0
0
0
0
0
9
0
0
0
92
0
0
% H
% Ile:
0
0
0
9
17
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
100
0
9
92
0
0
0
0
0
9
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
59
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
17
0
0
92
0
% P
% Gln:
0
0
0
0
0
0
0
0
59
9
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% R
% Ser:
0
75
0
0
0
0
0
0
0
17
0
0
0
0
84
% S
% Thr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
84
0
84
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _